切片非常漂亮，谢谢提供这么好的学习资料。 
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- B1758乳腺癌，化疗后，有两种成分。
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| 姓 名： | ××× | 性别： | 女 | 年龄： | 55 |
| 标本名称： | 乳腺改良根治标本 | ||||
| 简要病史： | 左乳肿物两月余，化疗2次后 | ||||
| 肉眼检查： | 一侧乳腺改良根治标本，肿物直径2cm，灰白质硬，界限不清。 | ||||
标签：乳腺浸润性导管癌 乳腺浸润性小叶癌 E-Cadherin p120
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本帖最后由 于 2009-01-15 19:52:00 编辑
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本帖最后由 于 2009-01-18 04:37:00 编辑
| 以下是引用dujun0522在2009-1-17 12:21:00的发言： 我们常规没有p120 ，可以进一些，再做些工作。 |
It can be very helpful. I showed some lobular lesions with p120 stain in my breast lesion case 7.. You can give a quick review if you like to.
http://www.ipathology.cn/Forum/forum_display.asp?classcode=129&keyno=111923&pageno=2
http://www.ipathology.cn/Forum/forum_display.asp?classcode=129&keyno=111923&pageno=1
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It is difficult to evaluate now. Maybe Dr 笃行者 was right there are two types of tumor. But E-cad stain showed weakly positive (it is true membrane stain). Generally we will add p120 stain for some unclear case. Her2 positive (score 3) is rarely seen in classic type of lobular carcinoma. E-cad stains are similar for all tumors. I am a little confused by this case. Chemotherapy can change the morphology of the cells and also the IHC reaction. Bottomline for this case is that your diagnosis (ducal, lobular or mix) will not change the continuous treatment for this patients.
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本帖最后由 于 2009-01-16 09:21:00 编辑
Interesting and beautiful photos. thank for sharing. The tumors in all photos with e-cad look positive. In one of your Her2 stain photos the tumor cells in right side are positive (Score 3), but the tumor cells may be score 1 in the left side. What is E-cad stain in this area?
Did you have the breast biopsy specimen of this patient before chemotherapy?
