The computer can release less than 1 quantile (about 10-20% in our practice) without been seen by human eyes. 

这句差的太多了， 谢谢 mingfuyu老师指正：

Focal Point 计算机可以出大概10-20%的宫颈涂片报告（release report), 这部分涂片是绝对正常，可以不经过人眼看（细胞技师或病理医生）。

新手上路 多多指点（飞龙and 师妹yinxiangli）

译文：

大家无须过于担心。我认为我暂时还不会失业。我想解释一下计算机辅助筛查在美国的应用。欢迎各位明天在网络教室对我提问。

我们就拥有2台计算机辅助筛选系统：Focal point和Imager系统。

Focal point使用ThinPrep slides， 计算机对涂片进行扫描后根据细胞核的异常程度将其分为四个级别。任何具有可疑细胞的涂片或没有宫颈细胞或其他标志的涂片将由细胞学技师进行人工复筛。计算机的敏感性可发现1级的差别（这部分病例在我们的实践中约占10-20％），然而这个微小差别是超出人眼睛所能分辨的。但绝大多数病例都必须细胞学技师进行检查。这种方法能节约细胞学技师的时间，但不是细胞病理诊断医师的时间。无论有无有Focal point，所有异常病例都必须经细胞病理学诊断医师进行诊断。

Imager系统是通过另外一种原理：对每张切片进行扫描，并将每张涂片上计算机所判断的异常细胞或者细胞团用20个激光点标记。虽然细胞学技师必须检视每张涂片，但是他们并不象Imager检测那样去检视所有细胞，而仅仅检视那20个激光点所标记的细胞并将这些疑似异常的细胞或细胞团用墨水做标记。这些含异常细胞的涂片将有细胞学病理诊断医师进行诊断。

HPV检查和疫苗能减少子宫颈涂片检查。如果一个女性高风险HPV病毒检测呈阴性，那么她可以3年内无需进行子宫颈抹片检查，然而如果在HPV检测技术应用之前，这部分病人则通常需每年进行一次宫颈涂片检查。HPV检验并不能用于宫颈抹片筛查，因为虽然很多人都HPV感染，但并不表现细胞异性型 。尤其是对年轻女性来讲，她们可以自我清除病毒感染。而对于30岁以的女性患者，HPV检查具有更大的价值。

非常感谢飞龙及小师妹的精彩准确翻译。太长了，对不起。

唯一有点出入的是下面这句。quantile 是比较复杂的一个概念，有点相当于percentile。Focal Point 计算机可以出大概10-20%的宫颈涂片报告（release report), 这部分涂片是绝对正常，可以不经过人眼看（细胞技师或病理医生）。

 计算机的敏感性可发现1级的差别（这部分病例在我们的实践中约占10-20％），然而这个微小差别是超出人眼睛所能分辨的。

 Don't worry, i still cannot see myself without job in near future.  But i would like to explain computer assisted screening in US.  You are welcome to ask me tomorrow in Jiao Shi.

We have 2 computer assisted screening systems: focal point and imager.

Focal point uses ThinPrep slides and computer scans the slides  and rank cases into 4 quantile depending on degree of cellular abnormality.  Any slide with any worrisome cells or normal slides without endocervical cells and other signs will be screened by cytotechnologists. The computer can release less than 1 quantile (about 10-20% in our practice) without been seen by human eyes.  But the most majority cases have to be seen by cytotechs.  It saves cytotech's time, but not pathologists' time.  With or without Focal Point, all abnormal cases have to be seen by pathologists.

Imager uses another mechanism: It screens slides and makes 20 laser dots on each slide labeling abnormal cells or groups judged by computer.  Every slide has to be seen by a cytotech.  But instead of looking at all the cells without Imager, the cytotech looks only the 20 laser dots and converts truely worrisome cells or groups to ink dots.  Abnormal slides go to pathologist.

HPV test and vaccine is reducing pap smear volume.  If a woman is tested high risk HPV negative, she can go for 3 years without pap smear, instead of yearly pap before HPV test era.  HPV test cannot be used to screen pap smears because many people have HPV infection but never have dyplasia.  Especially young people, they clear up the virus by themself.  In women older than 30 years old, HPV test is more useful.

It is a long message but it started with a complicated question.  I found many people have this kind of question.  So i took time to explain.

Thanks for translation.

 It is not true. Never trust these people. The number of Pap test may be reduced in future in the US because pf the use HPV vaccine and HPV testing. Some people recommended HPV testing for all women age 30 above. Pap test will be done if the women's high risk HPV testing is positive. There is still a long way, especially in China.

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