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liguoxia71 离线
IHC:
smooth muscle markers
Calretinin, inhibin
Epithelial markers
Did you see the both normal ovaries?
Based on the morphology, I feel it looks like an ovarian sex cord-stromal tumor, fibromatous tumor or fibrothecoma. Calretinin and infibin can be focally positive in these tumors. If it is a fibromatous tumor, you need to check mitosis and cytologic atypia carefully to see if it is malignant, like fibrothecoma. Malignant fibrous tumor is very few in ovary. Of cause it may be a smooth muscle tumor.
Anyway IHC stains are needed in this case.
以下是引用cqzhao在2008-12-3 13:26:00的发言:
IHC: smooth muscle markers Calretinin, inhibin Epithelial markers Did you see the both normal ovaries? Based on the morphology, I feel it looks like an ovarian sex cord-stromal tumor, fibromatous tumor or fibrothecoma. Calretinin and infibin can be focally positive in these tumors. If it is a fibromatous tumor, you need to check mitosis and cytologic atypia carefully to see if it is malignant, like fibrothecoma. Malignant fibrous tumor is very few in ovary. Of cause it may be a smooth muscle tumor. Anyway IHC stains are needed in this case. |
译文:需要做平滑肌标记、calretinin、抑制素和上皮性标记。你看到了两个正常的卵巢吗?
根据这些形态,我感觉象卵巢性索间质肿瘤,纤维瘤或纤维卵泡膜瘤。calretinin和抑制素在这些肿瘤中可呈局灶性阳性。如果它是纤维瘤,你应该象纤维卵泡膜瘤一样,需要认真地观察核分裂和细胞异型性以判断它是否为恶性,卵巢恶性纤维性肿瘤非常少见。当然它可能是一个平滑肌源性肿瘤。
无论如何,这例需要做免疫标记。