59 year old man with mastoid mass (ss112108)

stevenshen 离线: 帖子：343; 粉蓝豆：2; 经验：343; 注册时间：2008-06-03; 加关注 | 发消息

楼主发表于 2008-11-22 08:45|举报|关注(0)
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姓名：	×××	性别：	年龄：
标本名称：	Mastoid biopsy
简要病史：
肉眼检查：	1.0x0.8x0.6 cm

Great discussion and comments! I did not include cytology imprint pictures. I am surprised that nobody is asking for it. Here are two pictures of cytology - it might be useful to narrow down your differential diagnosis and immunohistochemical workup.

图1
图2
图3
图4

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本帖最后由于 2008-11-30 05:15:00 编辑

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×参考诊断

Large B cell lymphoma

stevenshen 离线: 帖子：343; 粉蓝豆：2; 经验：343; 注册时间：2008-06-03; 加关注 | 发消息

21 楼发表于2008-11-30 22:12:00举报|引用
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Two photos from intraoperative touch imprint cytology uploaded. They should be helpful.

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mjma 离线: 帖子：703; 粉蓝豆：24; 经验：789; 注册时间：2006-09-28; 加关注 | 发消息

22 楼发表于2008-11-29 07:57:00举报|引用
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Differential diagnoses include lymphoma (including NK/T cell lymphoma), neuroendocrine carcinoma (including small cell carcinoma), peripheral PNET/extraskeletal Ewing sarcoma and rhabdomyosarcoma. I favor T cell lymphoma. AE1, Cam5.2, CD3, CD20, CD43, CD56 and/or CD57, CD79a, desmin, TTF-1 and synaptophysin would be my choices of initial IHC workup.