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| 名称： | |
| 描述： | |
- B1730乳腺肿物
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| 姓 名： | ××× | 性别： | 女26 | 年龄： | |
| 标本名称： | 左乳腺肿物一年 | ||||
| 简要病史： | |||||
| 肉眼检查： | 肿物8.5*6.5*4.5切面囊性囊内充满干酪样物, | ||||
标签：乳腺颗粒细胞瘤 组织细胞肿瘤 分泌性癌
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×参考诊断
Interesting case.
I cannot see the tumor edge in above photos. My differential dx includes ruptured cysts with a granulomatous reaction, a histiocytic tumor, apocrin carcinoma, and granular cell tumor (GCT). The cytomorphology of the last two photos are really consistent with GCT.
Suggest IHC:
Pan cytokeratin, EMA: mammary ca is positive, histiocyte or GCT is negative
S-100: strongly positive for GCT
alpha-antitrypsin: Histiocytes are positive, GCT is negative.
CD68: Strongly and diffusely positive for histiocyte; GCT may be focal positive or negative
Hope to see your follow-up
| 以下是引用cqzhao在2008-11-21 11:13:00的发言：
Interesting case. I cannot see the tumor edge in above photos. My differential dx includes ruptured cysts with a granulomatous reaction, a histiocytic tumor, apocrin carcinoma, and granular cell tumor (GCT). The cytomorphology of the last two photos are really consistent with GCT. Suggest IHC: Pan cytokeratin, EMA: mammary ca is positive, histiocyte or GCT is negative S-100: strongly positive for GCT alpha-antitrypsin: Histiocytes are positive, GCT is negative. CD68: Strongly and diffusely positive for histiocyte; GCT may be focal positive or negative Hope to see your follow-up
大概翻译: 上述图片中我看不到肿瘤的边界, 我认为需要鉴别的鉴别诊断包括囊肿破裂引起的肉芽肿反应; 组织细胞肿瘤, 分泌性癌, 颗粒细胞瘤 最后两张的图片上看该细胞形态学,符合颗粒细胞瘤. 建议免疫组化: CK-P,EMA乳腺癌是阳性的,组织细胞或颗粒细胞是阴性的 S-100: 颗粒细胞为强阳性 alpha-antitrypsin 组织细胞是阳性的,颗粒细胞是阴性的 CD68: 组织细胞是广泛的强阳性,颗粒细胞是局灶的阳性或阴性的
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