Thanks for your all input. This is a tough case. It is a partial atrophy.

Partial atrophy is the most common mimicker of prostate adenocarcinoma. Partial atrophy has a certin amount of cytoplsm, which is normally pale stained. It can have infiltrative pattern. Partial atrophic glands have infolding in the lumen. You can see small nucleoli, not like the one in cancer-large melanoma-like eosinophilic nucleoli. When you performe immunostain, partial atrophy normally have at least partchy basal cell stain. However, it is not uncommon you can see negative basl call stain. We see those suspicious stain almost everyday. Partial atrophy can be positive for AMACR. When you have partial atrophy with negative basal stain and positive AMACR, which is a cancer pattern, it is very confusing. Please pay attention to this mimicker.

I just want to bring you attention to it so that nobody make a mistake to make a benign partial atrophy as cancer.

 图片太少，有点象前列腺泡沫腺癌。

 前列腺癌

 关注中！！

pathdoc  老师的英文 我看不明白啊      是萎缩？？？  请求老师翻译！！

这个病例很有意思  期待讲解！！！

 试一试翻译。部分萎缩通常与前列腺腺癌很相似。 部份萎缩有一定量的胞浆，胞浆淡然。 局部萎缩可以浸润生长。 部分萎缩的腺体向基底膜凸出。 这些腺体有小核仁，不同于前列腺癌的类似于恶性黑色素瘤的大嗜伊红的核仁。 免疫标记具有部分的基底细胞标记。 然而，标记阴性的基底细胞也不常见。 几乎我们都看见那些可疑的阳性标记。 部份萎缩AMACR标记阳性。 部份萎缩呈癌的生长方式，基底细胞标记阴性，且AMACR标记阳性时，很容易混淆。 请注意两者的这些相似性。I我想要提醒您不要犯把良性部份萎缩诊断为癌这样的错误。

请pathdoc老师及各位老师指教。呵呵

partial atrophy