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Favour endocervical adenocarcinoma, DDx endommetrioid adenicarcinoma.
Clinical very important - speak to the gynaecologist to ask where the bulk of tumour is!
IPX helpful:
Endocervvical ca; CEA+ Vimentin -. p16+
Endometrioid ca: CEA-, Vimentin +. CD10+. ER+. PR+
(quoted from pathologyoutlines.com -Endocervical adenocarcinoma Positive stains: Alcian blue, mucicarmine, CEA, keratin, EMA, p16, ER and PR in 25%, p53
Negative stains: CD10 (positive only in mesonephric adenocarcinomas), p63 (Hum Path 2001;32:479), vimentin (usually)
Molecular: associated with HPV 16 and 18 in 85-95% of cases (AJCP 1996;106:52, Br J Cancer 2005;93:1301)
DD: endometrioid adenocarcinoma extending to cervix (no in situ cervical adenocarcinoma, continuity between cervix and endometrial tumors, usually myometrial invasion, often bland squamous differentiation; stains may be helpful - negative or focal/superficial for CEA and mucin; positive for vimentin, ER and PR, negative for HPV by PCR,)
vitamin-xbl 离线