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zhangyajing 离线
Very good photo quality. Thank you 楼主.
Dx: High grade papillary urothelial carcinoma because: 1. nuclear chromasia (fig 13) and coarse chromatin. 2, almost all nuclei have prominent nucleoli. 3, Nuclear pleomorphism (some nuclei are three times larger than smaller ones). 4. Nuclear membrane irregularity. 5. mitosis can be seen far away from the basement membrane. 6. a good portion of the neoplastic cells loss orientation that should be perpendicular to the basement membrane. 7. Low power view shows papillary branching and fusion. 8. patient's age
However, this should be the low end of the spectrum of high grade urothelial carcinoma. Careful search might reveal some focal microinvasion.or urothelial carcinoma in situ.