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- 2010年9月25日， 徐浩东老师（美国）主题：IMP3 and Lung Cancer
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Dr. Xu is a pulmonary expert pathologist, one of a few pathologists who do the clinical work and also have their own lab for basic medical （基础医学）research. Most pathologists in the University hospitals do some research called transitional research, but not basic medical research.
Haodong Xu, MD, PhD
Contact Information
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 626
Rochester, NY 14642
Office: (585) 275-0857
Fax: (585) 273-3637
Lab Description
Professional Bio
Residency training in Anatomic Pathology, Washington University School of Medicine. Fellowship in Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology. Board certified in Anatomic Pathology. My primary clinical interests are in pulmonary and mediastinal pathology.
Research Bio
My research is focused on delineating the mechanisms in the regulation of voltage-gated potassium channels underlying the cardiac repolarization. Ongoing studies are focused on defining the functional roles of filamin C, an actin binding protein, in the regulation of both voltage-gated potassium channels and cardiac contraction. In addition, my interests also include molecular mechanisms of lung tumor and fibrosing interstitial pneumonia.
Awards & Honors
| Applications of patch-clamp techniques", third prize from the National Institute of Health in P.R. China. | 1996 |
| My thesis was given "Excellent Thesis Award" at the Fourth Symposium on Cardiology, Xian, China. | 1993 - 1993 |
| My thesis was given "Outstanding Youth's Thesis Award" at the Sixth Symposium Cardiac Pacing and Electrophysiology, Wuhan, P.R. China | 1992 - 1992 |
| Zhou, Wenxun Scholarship | 1992 |
| Class President for M.S. | 1987 - 1990 |
| Excellent Student Award", Suzhou Medical College | 1982 - 1987 |
| Class President, Suzhou Medical College | 1982 - 1987 |
Recent Journal Articles
Showing the 5 most recent journal articles. 51 available »
| Yu L, Xu H, Wasco MJ, Bourne PA, Ma L. "IMP-3 expression in melanocytic lesions." Journal of cutaneous pathology. 2010; 37(3):316-22. Epub 2009 Sep 24. |
| Findeis-Hosey JJ, Yang Q, Spaulding BO, Wang HL, Xu H. "IMP3 expression is correlated with histologic grade of lung adenocarcinoma." Human pathology. 2010; 41(4):477-84. Epub 2009 Dec 11. |
| Levy M, Lin F, Xu H, Dhall D, Spaulding BO, Wang HL. "S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy." Human pathology. 2010; Epub 2010 Apr 09. |
| Hu Y, Yang Q, McMahon LA, Wang HL, Xu H. "Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor." Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry. 2010; Epub 2010 Apr 27. |
| Manganaris C, Wittlin S, Xu H, Gurell M, Sime P, Kottmann RM. "Metastatic papillary thyroid carcinoma and severe airflow obstruction." Chest. 2010; 138(3):738-42. |
Current Appointments
| Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary Appointment |
| Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) |
Board Certified Specialties
| Anatomic Pathology - American Board of Pathology |
Education
| PhD | Cardiac Physiology | Soochow University Medical School | 1993 |
| MS | Circulation Physiology | Soochow University Medical School | 1990 |
| MD | Medicine | Soochow University Medical School | 1987 |
Post-Doctoral Training & Residency
| Fellowship in Pathology at Armed Forces Medical College | 07/01/2003 - 06/30/2004 |
| Residency in Anatomic Pathology at Barnes-Jewish Hospitals | 07/01/1999 - 06/30/2003 |
Xu Lab
Research Overview
Arrhythmias remain a major health problem, causing at least 250,000 deaths annually in the United States. Dr. Xu's long term goal is to elucidate molecular signaling pathways involving the development of cardiac arrhythmias so that therapeutic targets for treatment and/or prevention can be identified. It has been shown that p90 ribosomal S6 kinase (p90RSK) activity is significantly increased in different types of cardiac diseases, in which QT-interval is prolonged, increasing the frequency of cardiac arrhythmia. In his lab, he has been exploiting a sophisticated combination of biochemical, electrophysiological and molecular techniques to define the molecular mechanism by which activation of p90RSK prolongs cardiac repolarization.
This mechanism would potentially predispose to arrhythmias via phosphorylating Kv4.3 alpha subunit, one main component of transient outward K+ current (Ito,f) channel and thus inhibiting this channel activity. Ongoing interests include studies focused on defining the functional roles of two delayed rectifier K+ currents, IKr and IKs modulation by p90RSK in the development of cardiac arrhythmias in diabetic cardiomyopathy and cardiac ischemia/reperfusion.
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