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姓 名: | ××× | 性别: | f | 年龄: | 52 |
标本名称: | Breast segmental mastectomy | ||||
简要病史: | Breast lesion | ||||
肉眼检查: |
failed to poste the photos and try again.
Your diagnosis
Differential diagnoses
What immunostains will be useful?
以下是引用Liu_Aijun在2008-10-5 11:06:00的发言:
这是导管内乳头状病变。需在“瘤”与“癌”之间鉴别。从HE看,细胞形态一致,核增大,圆形或卵圆形,染色质丰富而细腻,可见1-2个小核仁。乳腺癌癌细胞的特点之一就是“太一致”,易被误为神经内分泌癌。从IHC看,肌上皮细胞在异型上皮细胞巢周围分布,而不是深入乳头轴心内。综上,考虑为导管内乳头状瘤伴重度不典型增生、癌变,或癌在导管内乳头状瘤内。 期待cqzhao老师的讲解! |
支持刘老师的看法!
请教cqzhao老师:是否需标记ER?在增生性病变,ER表达分布不均匀,而在癌则是弥漫强阳性,不知对否?请赐教。谢谢!
这是导管内乳头状病变。需在“瘤”与“癌”之间鉴别。从HE看,细胞形态一致,核增大,圆形或卵圆形,染色质丰富而细腻,可见1-2个小核仁。乳腺癌癌细胞的特点之一就是“太一致”,易被误为神经内分泌癌。从IHC看,肌上皮细胞在异型上皮细胞巢周围分布,而不是深入乳头轴心内。综上,考虑为导管内乳头状瘤伴重度不典型增生、癌变,或癌在导管内乳头状瘤内。
期待cqzhao老师的讲解!
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Key for Figures:
1. 10x smooth muscle myosin heavy chain (SMMHC)
2. 10x SMMHC
3. 10x SMMHC tumor edge
4. 20x SMMHC
5. 10x p63
6. 10x p63
7. 10x p63 tumor edge
Now you have the IHC results. Please write down your dx. Is it the same as the one you though before? This is a challenge case. Very happy to know all friends' dx and discussion. It is better to write your diagnosis and also explain why. As pathologists we make diagnosis for our cases based on the reasons.
I will join the discussion few weeks later,
Thnaks,
cqz