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患者56岁,乳腺穿刺诊断查到癌细胞,化疗几个疗程后做手术,手术后标本未找到肿物
病理报告:乳腺癌化疗后反应。
是否化疗能把肿物消除?穿刺诊断是否可以直接发?
请各位老师指点
找到癌细胞。
理由:细胞量丰富,异型,与脂肪组织掺杂。
个人认为,乳腺细胞学有时无法判别浸润性癌或原位管内癌,但是,本例异型细胞与脂肪如此密切地纠缠,觉得是浸润脂肪。
病灶小,化疗后病灶消失或是可能的。
建议,保管好原始涂片,按规范阳性涂片是不外借的,需要会诊时可请专家到科里来看。
认真仔细检查切下的标本,看看有没有可能小结节性病灶遗漏了。
另外,提醒患者的母亲、姐妹、女儿应该注意预防乳腺癌。
必要时,还能做显微镜下脱氧核糖核算的分割量化(梁英杰老师的研究),用米勒博士的作法(迈新会议上的介绍)也能用细胞胶的办法用来做局部的免疫化学标记,当然还有DNA 分析。
长期随访,病人还可能复发。
病理医生,乃至医务界都应该面对医疗现状的现实。实事求是,客观冷静地行医、处事。
We have recently 2 cases with similar story, core biopsy dx was DCIS and lumpectomy found no cancer. Our approach was: multiple deeper sections to looking for scar or biopsy site granulation to make sure we got correct tissue/site, if not found, turned the block around (flip over) and cut again.
One case we did not find anything, multiple communication with surgeon and make sure he understand the situation. 2nd case, DCIS was found after flipped over the block.
Breast lesion here is a big deal, and complecated issue. First time biopsy usually (perfer tissue rather than cytology) left a small metal marker inside the biopsy site for future locatoin under X-ray. lumpectomy specimen comes to us with X-ray film showing the marker and lesion.
For your case, it certainly chemotherapy may kill (cure) the cancer, congradulations.