为什么在切片里，很多的化生细胞都有明显的核仁，但在细胞学里，一般说有核仁的都是修复细胞，化生细胞没有明显的核仁？脱落的化生细胞难道说真的没有核仁吗？有没有把有核仁的化生细胞误认为是修复细胞呢？

还有鳞癌（高化分除外），在切片里，也有很明显的核仁，而核仁又作为论断腺癌的一个标准，这里面是不是也会引起判断错误呢？

我也有类似的疑问哦，希望能得到的解答的，谢谢

 Sorry i have to type English.

I feel nucleolus is a very simplified concept in pathology teaching.  The classic teaching is:  you see nucleoli in invasive SCC and reparative cells.  But in real life what you observed is absolutely true.  You can see nucleoli in many situations .  You certainly can see it in metaplastic cells.  Please note that many cervical/endocervical smears have inflammation, so those metaplastic cells show nucleoli as reactive changes.  You do see nucleoli in invasive SCC and adenocarcinoma but the chromatin is much darker in SCC than in adeno.  Always remember you can never use one or two rules to assess a specimen.  The American saying for that is:  all the rules are made to break.  It means:

Pay attention to CIN next time.  You can even see nucleoli in CINs.