首先考虑一下转移性腺癌

 上皮来源的恶性肿瘤.转移性腺癌.

 转移癌

 转移癌，图一图2中不知是否沙粒体结构，检查生殖系统、甲状腺、肺等部位。

冰对切片出来了，感觉像脉络丛乳头状瘤，想上传切片未能成功，请城北帮我一下如何？谢谢！

 This is not a choroid plexus papilloma. It is a metastatic adenocarcinoma. A psammoma body is formed, but cytology and glandular architecture are not benign. Choroid plexus carcinoma is almost unheard of in an adult. In a relatively young woman like this, metastatic adenocarcinoma generates many possible origins to search the primary in - breast and lung remains the most possible by statistics, but other sources like ovary/uterus, urinary bladder, kidney, and pancreas cannot vbe overlooked, either. 

 

马老师的帖子翻译如下:This is not a choroid plexus papilloma. 这不是脉络丛乳头状瘤,It is a metastatic adenocarcinoma. 而是转移性腺癌.A psammoma body is formed, but cytology and glandular architecture are not benign. 有砂粒体形成,而且细胞结构和腺休结构都有异形性.Choroid plexus carcinoma is almost unheard of in an adult.成人的脉络丛癌还没有报导过. In a relatively young woman like this, metastatic adenocarcinoma generates many possible origins to search the primary in - breast and lung remains the most possible by statistics, but other sources like ovary/uterus, urinary bladder, kidney, and pancreas cannot vbe overlooked, either.  像这些相对年青的女性来说,脑转移性腺癌多数来源于乳腺,肺,也有其它来源的,如卵巢,子宫,膀胱,肾,胰腺,等.

 冰对切片

 谢谢马老师和月新老师，免疫组化有助于鉴别诊断吗？

TTF-1 (lung adenocarcinoma) and GCDFP-15 (papillary carcinoma from breast) immunohistochemical stains can certainly help, especially if either one is positive. But neither lung nor breast could be ruled out as the primary origin if both markers were negative. The new photos uploaded show a papillary adenocarcinoma with features suggestive of serous adenocarcinoma of mullerian origin (uterus, ovary and peritoneum). Most Mullerian serous adenocarcinomas are high grade, and disease recurrence pattern is usually metastatic disease to pelvic and para-aortic lymph nodes and/or elsewhere in the peritoneal cavity. Metastasis to brain without abdominal or nodal disease is rare. Do we know if the patient has any abdominal disease (abdominal pain, ascites, pelvic pain) or a positive history of gynecologic cancer?

 马老师的帖子翻译如下:    TTF-1 (lung adenocarcinoma) and GCDFP-15 (papillary carcinoma from breast) immunohistochemical stains can certainly help, especially if either one is positive. 免疫组化可以帮助查找肿瘤来源，肺腺癌免疫组化做TTF-1，乳腺的乳头状腺癌免疫组化做GCDFP-15有助于诊断，特别是如果其中一项是阳性，有帮助。But neither lung nor breast could be ruled out as the primary origin if both markers were negative. 但两项都是阴性时,肺和乳腺起源均不能排除。The new photos uploaded show a papillary adenocarcinoma with features suggestive of serous adenocarcinoma of mullerian origin (uterus, ovary and peritoneum).新上传的图像显示明显的乳头状腺癌的特点，可以考虑苗勒氏管来源的浆液性腺癌，如子宫，卵巢和腹膜。 Most Mullerian serous adenocarcinomas are high grade, and disease recurrence pattern is usually metastatic disease to pelvic and para-aortic lymph nodes and/or elsewhere in the peritoneal cavity. 多数苗勒氏管的浆液性腺癌是高分化的，肿瘤复发常常转移到盆腔和腹腔主动脉旁淋巴结，或者转移到腹腔的其它部位。Metastasis to brain without abdominal or nodal disease is rare. 无腹部和淋巴结转移，直接转移到脑，较罕见。Do we know if the patient has any abdominal disease (abdominal pain, ascites, pelvic pain) or a positive history of gynecologic cancer? 不知该患者有无腹部疾病，如腹部疼痛，腹水，盆腔疼痛，也不知道患者有无妇科肿瘤的病史？

 

 But neither lung nor breast could be ruled out as the primary origin if both markers were negative. 反之，如果两项都是阴性的话，可以考虑既不是乳腺来源也不是肺腺癌起源。

感觉这句的翻译是否欠妥！

 感谢二位帮助,的确是翻译有误.已经改过了.翻译不是简单的事.一不溜神就出错.

但两项都阴性时，肺和乳腺起源均不能排除。

 感谢楼上三位朋友!!

 期待结果中

 感谢各位的严谨！

 谢谢楼上的各位老师，这个标本是外院术中临时决定送我院做冰冻的，当时冰冻报告：恶性肿瘤，倾向转移腺癌。至今没有随访到这个病人，我们用冰对组织做了下面一些免疫标记：GFAP（-）EMA（+）TTF-1（+）S-100（+-）