Certainly lymohoma (Hodgkin and non-Hodgkin type alike) and infectious lymphadenitis (such as infectious mononucleosis caused by Epstein-Barr virus infection) are to be ruled out. This would be difficult to achieve without the use of immunohistochemistry and other ancillary tests (such as molecular tests for immunoglobulin or T cell receptor gene rearrangements, detection of EBV DNA). These additional tests are of immense importance un hematopathology and should be done whenever lymphoma is a possibility. In this case, I suggest starting with CD30, ALK1, CD15, EMA, CD20, CD79a, CD3, CD45RO, CD56 and EBV. Interesting case! Love to know the final diagnosis and test results.
Certainly lymohoma (Hodgkin and non-Hodgkin type alike) and infectious lymphadenitis (such as infectious mononucleosis caused by Epstein-Barr virus infection) are to be ruled out. This would be difficult to achieve without the use of immunohistochemistry and other ancillary tests (such as molecular tests for immunoglobulin or T cell receptor gene rearrangements, detection of EBV DNA). These additional tests are of immense importance un hematopathology and should be done whenever lymphoma is a possibility. In this case, I suggest starting with CD30, ALK1, CD15, EMA, CD20, CD79a, CD3, CD45RO, CD56 and EBV. Interesting case! Love to know the final diagnosis and test results.