It is too bad that some of the photos were taken out of focus. I could not identify nucleoli, chromatin pattern, nuclear membrane or mitotic figure at all. Could you try to take more photos of better quality and upload to share with us?

The neoplasm consists of a relatively uniform population of small cells with little cytoplasm and no distinctive features of differentiation. Calcification is present. Are there necrosis, vascular/endothelial proliferation, or readily seen mitotic figures? Are there rosettes of any kind? Without perivascular arrangement, I would not favor lymphoma. More worthy of consideration would be a primitive neuroectodermal tumor (PNET) and a small cell glioblastoma. Immunostains are needed for clarification, to include CD45, AE1, synaptophysin, NSE, GFAP and MIB-1. Look forward to hearing more about this case.

 Are there necrosis, vascular/endothelial proliferation, or readily seen mitotic figures? Are there rosettes of any kind?

Answer:First of all ,thank you for consulting my uploaded case.Because it is not my case but a consultant case. So no more detail can be provided. Sorry! Please forgive me. As for your above questions,I would say no necrosis and endothelial proliferation.no mitotic figures and roseetes of any kind.some cells have clear and defined cell mebrane whihc remind somebody of 少枝．但有的地区间变很厉害．所以大家讨论的意见考虑是否为间变性少枝