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Adenoid basal cell tumor (adenoid cystic-like tumor; basal
cell carcinoma). 432,436 This neoplastic process resembles
adenoid cystic carcinoma of the salivary gland, to the point
that some authors have regarded it as analogous to the
latter. 452,462 However, the natural history of this tumor is much
more indolent than that of the bona fide adenoid cystic
carcinoma. 432,486 The key microscopic features are expansile
pattern of growth, multinodularity, a cribriform architecture
with luminal-basal lamina-like material, a surrounding
fibromyxoid stroma, common occurrence of squamous
differentiation, and merging with foci of basal cell hyperplasia
(from which it may have arisen) (Fig. 18.28). PAP and PSA
staining is negative or focally positive. The differential
diagnosis includes basal cell hyperplasia, acinar
adenocarcinoma with cribriform pattern of growth, basaloid
carcinoma (see immediately below) and true adenoid cystic
carcinoma. Regarding the latter, if such a tumor exists in the
prostate it must be a rare occurrence indeed. As for the
alternative term basal cell carcinoma, it should be avoided on
morphologic and behavioral grounds.
腺样基底细胞肿瘤(腺样cystic-like肿瘤;基底
细胞癌)。这个肿瘤类似唾腺的腺样囊性癌
一些作者认为它类似于基底细胞癌。
然而,这种肿瘤的愈后是远比真正的腺样囊性
癌好。此种肿瘤的形态学关键特点是膨胀性
增长模式,多结节性,围有基底细胞样腔壮的筛状结构,
周围纤维基质,常见的鳞状分化,和合并基底细胞增生
它可能导致PAP和PSA阴性或局部阳性
要注意包括基底细胞增生,腺泡腺癌伴有筛状增长,
基底细胞癌和真正的腺样囊腺癌之间的区别。关于腺样
囊腺癌,这样的肿瘤中存在前列腺确实很少见。至于基底
细胞癌,应该要避免以形态和行为依据。