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A case from my friend: 63 yo M lung nodules. Big nodule is positive for both ck7 and TTF-1, and small nodule negative for both. The pleural nodule is negative for both ck7 and TTF-1. How do you explain the immunoprofile? All nodules are negative for ck20. There are 7/8 positive lymph nodes. No any other cancer history! -3