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姓 名: | ××× | 性别: | 女 | 年龄: | 55岁 |
标本名称: | 全子宫及腔内肿瘤剥除 | ||||
简要病史: | 不规则阴道流血,临床诊断:子宫黏膜下平滑肌瘤 | ||||
肉眼检查: | 宫内肿瘤(分离的)6cm×3cm×2cm,切面灰黄色,局部有微囊,内含暗红色浑浊液体。 |
组织学图像较一致,肿瘤表面部分可见宫腔表面黏膜上皮。
知之者不如好之者,好之者不如乐之者。(语出幽梦影)
以下是引用城北在2008-3-4 11:55:00的发言:
免疫组织化学检测结果,图片明天附上 DES 弥漫 +++ 、SMA弥漫++ 、CD99弥漫++ 、广谱CK弥漫+、Vim弥漫+++、CD10 -、AE1 -,其他暂时未作 |
Interesting case! Thank you for sharing.
I agree with most opinion here that this is most likely a UTRODCT (Uterine tumor resembling ovarian sex cord tumor). Based on recent studies and progress, this tumor further divided into two groups of tumors: 1. Endometrial stromal tumor with sex cord-like elements (ESTSCLE); 2. UTROSCT.
In ESTSCLE, the sex cord component constitutes a minor portion of an endometrial stromal tumor. In UTROSCT, it is predominant or exclusive component of a uterine wall lesion composed of a variety of mesenchymal elements. Therefore, UTROSCT is pathogenetically more heterogenous. To differentiate this tumor from usual smooth muscle or endometrial stromal tumor, it is important to confirm the sex-cord element. A panell of following 4 immunohistochemical markers is recommended as the most reliable markers for confirming sex cord component: Calretinin, CD99, Inhibin and MelanA. Among them Caretinin is the most sensitive marker. ESTSCLE usually only expresses one maker, mostly calretinin. Calretinin positivity plus any one of three other markers mentioned above may thus confirm the diagnosis of UTROSCT.
There is a good review paper just published on International Journal of Gynecologic Pathology in 2008 by Dr. Czernobilsky. I have the PDF file. If anybody interested in reading this paper, please send me an email and leave your email address to me.
I hope this is helpful to you all.