刘从容教授 ：高级别浆液性癌伴局灶STIC。p53（如果组化肿瘤细胞完全阴性，而周围正常细胞深浅不一弱阳性）具有无意义突变；由于偶然发现的STIC和早期高级别浆液性癌部分会有盆腔播散和转移。有妇瘤专家认为应该进行预防性化疗。目前争议中，关于p53组化染色，只有肿瘤细胞完全阴性（同时周围正常可见散在强弱不一的信号），才提示无意义突变。高级别浆液性癌中约10-15%的病例经基因测序后证实的确没有p53突变。

江庆萍老师：第一二张有正常输卵管上皮到异常的移行；

孔祥田老师：这个病例送到了Johns Hopkins University and confirmed by Dr Kurman. He did all the IHC and reported High grade Serous Carcinoma. In comment, he said p53 negative is unusual for this case. He did not mention p53 null mutation in his report. He did not mention STIC either. But I believe the STIC is there since this is the primary lesion in the Fallopian tube. The contralateral Fallopian tube is negative for carcinoma, the uterus is negative too except leiomyomata. But the patient will be followed because of this incidental finding! Thanks for the discussion.