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panzenggang 离线
panzenggang 离线
panzenggang 离线
panzenggang 离线
Oncocytoma | ||||||||||||||||||||||||||||||||||
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Clinical Futures | ||||||||||||||||||||||||||||||||||
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· Most common benign solid renal tumor; · Originate from the intercalated cells of the collecting duct; · 3-7% of all renal tumor, 2-12% multifocal, and 4-14% bilateral; · M:F= 2-3:1; · Mean patient age is 62-68; · 10% of cases, oncocytoma and chromophobe RCC may coexist. | |||||||||||||||||||||||||||||||||
Gross Findings | ||||||||||||||||||||||||||||||||||
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· Spherical and are large (average size, 7 cm) with a pseudocapsule or no capsule; · Cut sections, homogeneously tan-pale yellow, mahogany color; · Characteristic fleshy/stellate central scar (33-54%); · Necrosis, hemorrhage and calcification may be present. | |||||||||||||||||||||||||||||||||
Microscopic Findings | ||||||||||||||||||||||||||||||||||
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· Large cells, granular eosinophilic cytoplasm; · Well-defined small nests, no sheet-like arrangement; · Nuclei: round/oval/smooth and round, minimal atypia, large nucleoli; · Some areas, the nests are separated by a loose hypocellular fibrous stroma. | |||||||||||||||||||||||||||||||||
Differential Diagnosis | ||||||||||||||||||||||||||||||||||
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Immunohistochemistry Staining | ||||||||||||||||||||||||||||||||||
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· Cathepsin H +, EMA+, CK7-scattered strong positive, CD117+ · RCC-, Vimentin-, CD10- · Colloid iron staining: focal positive | |||||||||||||||||||||||||||||||||
Election Microscopy | ||||||||||||||||||||||||||||||||||
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· Abundant abnormal mitochondria | |||||||||||||||||||||||||||||||||
Cytogenetics | ||||||||||||||||||||||||||||||||||
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· Losses of chromosome 1 and X chromosomes, deletion of chromosome 14 and a balanced translocation involving 11q13. | |||||||||||||||||||||||||||||||||
Treatment and Prognosis | ||||||||||||||||||||||||||||||||||
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· Benign tumors, and the prognosis after total or partial nephrectomy is excellent. | |||||||||||||||||||||||||||||||||
Reference | ||||||||||||||||||||||||||||||||||
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· http://emedicine.com/radio/topic484.htm · AFIP, 4th series · Essential of Anatomic Pathology. Liang Cheng. 2nd Edition. |
Discussion: Zenggang Pan, MD, PhD. www.enjoypath.com
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