be careful to make dignosis of GBM in children

 According to HE morphology, I consider it as pleomorphic xanthoastrocytoma . We should be careful to make dignosis of GBM in children.

 胶质母细胞瘤

 AT/RT?

 Although some cells appear epithelioid with plump eosinophilic or clear cytoplasm, this malignant neoplasm consists predominantly of pleomorphic cells with eosinophilic fibrillary cytoplasm and brisk mitotic activity that are most consistent with WHO grade IV glioblastoma. s there any focus of necrosis and/or vascular proliferation? Several differential diagnoses need to be ruled out by careful examination of routine HE-stained sections and, perhaps, immunohistochemical stains (GFAP, EMA, AE1). They include choroid plexus carcinoma (AE1, EMA), atypical teratoid/rhabdoid tumor, supratentorial PNET and pleomorphic xanthoastrocytoma (unlikely in the presence of easily seen mitoses).

最后诊断：多形性胶质母细胞瘤（glioblastoma multiforme,GBM, WHO grade IV）

IHC：GFAP、vimentin均（+），EMA、CK等均（-）。

 

胶质母细胞瘤

 study.Thank you so much!