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- 我院实习学生，手指指甲中间色素，我拍的大体照片，还没有切，请问有老师见过这样大体的么
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请见国外参考文献。
1. J Am Acad Dermatol. 1996 May;34(
Nail matrix nevi: a clinical and histopathologic study of twenty-two patients.
Tosti A, Baran R, Piraccini BM, Cameli N, Fanti PA.
Abstract
BACKGROUND:
Because most dermatologists do not regularly perform biopsies of longitudinal melanonychia, even when the pigmentation presents as a single band, the true prevalence of nail matrix nevi is unknown.
OBJECTIVE:
Our purpose was to determine the prevalence of nail matrix nevi in white patients with longitudinal melanonychia involving a single digit and to determine whether longitudinal melanonychia caused by a nail matrix nevus can be clinically distinguished from longitudinal melanonychia from other causes.
METHODS:
From January 1989 to December 1994 we performed a nail biopsy on 100 of 128 consecutive white patients who had a single band of "idiopathic" longitudinal melanonychia.
RESULTS:
A nail matrix nevus was detected in 22 patients. A junctional nevus was found in 19 specimens and a compound nevus in three specimens.
CONCLUSION:
Nail matrix nevi in Caucasian patients are uncommon but not exceptional. The number of nevi presenting with longitudinal melanonychia exceeded that of melanoma. The diagnosis of nail matrix nevi is impossible clinically and always requires histopathologic study. The pathologic features of nail matrix nevi are similar to those of skin nevi except for their architectural pattern, which reflects the peculiar anatomy of the nail unit
.
2. Cutis. 2001 May;67(5):409-11.
Evaluation of pigmented lesions of the nail unit.
Abstract
Acquired pigmentary changes of the nail are secondary to a number of etiologies. These include nail matrix nevi; physical induction secondary to trauma; malignant melanoma; nutritional deficiencies; inflammation secondary to lichen planus; endocrine causes such as Addison's disease; or secondary to bacterial, fungal, or viral infections. The most important task faced by clinicians is to distinguish benign from malignant etiologies of nail pigmentation. We will briefly review the various entities that can yield dyspigmentation and their differentiation from melanoma of the nail.
3. Ann Dermatol Venereol. 2004 Nov;131(11):984-6.
[Nail unit blue melanocyte nevi: 2 case reports].
[Article in French]
Moulonguet-Michau I, Abimelec P.
Abstract
INTRODUCTION:
Nail unit blue nevus is a rare and benign melanocyte proliferation of the nail unit matrix.
OBSERVATIONS:
We report two cases of nail matrix blue nevi with a blue-black spot of the lunular area associated in the first case with a longitudinal nail groove.
COMMENTS:
The analysis of our cases and of the previously reported cases give us the opportunity to describe different clinical and histological presentations.
4. J Am Acad Dermatol. 2006 Apr;54(4):664-7.
Melanotic macule of nail unit and its clinicopathologic spectrum.
Husain S, Scher RK, Silvers DN, Ackerman AB.
Abstract
The clinical and histologic spectrum of melanotic macule of the nail unit is examined and the differences in the clinical appearance of longitudinal melanochychia caused by melanotic macule and by other kinds of proliferations of melanocytes are assessed. We observed that the clinical appearance of the pigmented band was of little help in establishing the underlying basic pathologic process. This underscores the importance of obtaining a biopsy of the nail matrix in patients who present with solitary longitudinal melanonychia.
5. Dermatol Res Pract. 2012;2012:353864. doi: 10.1155/2012/353864. Epub 2012 Mar 14.
Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study.
Di Chiacchio N, Loureiro WR, Michalany NS, Kezam Gabriel FV.
Abstract
Longitudinal melanonychia can be caused by melanocyte activation (hypermelanosis) or proliferation (lentigo, nevus or melanoma). Histopathologic examination is mandatory for suspicious cases of melanomas. Tangential biopsy of the matrix is an elegant technique avoiding nail plate dystrophy, but it was unknown whether the depth of the sample obtained by this method is adequate for histopathologic diagnosis. Twenty-two patients with longitudinal melanonychia striata were submitted to tangential matrix biopsies described by Haneke. The tissue was stained with hematoxylin-eosin and the specimens were measured at 3 distinct points according to the total thickness: largest (A), intermediate (B) and narrowest (C) then divided into 4 groups according to the histopathologic diagnosis (G1: hypermelanosis; G2: lentigos; G3: nevus; G4: melanoma). The lesions were measured using the same method. The mean specimen/lesion thickness measure values for each group was: G1: 0,59/0,10 mm, G2: 0,67/0,08 mm, G3: 0,52/0,05 mm, G4: 0,58/0,10 mm. The general average thickness for all the specimens/lesions was 0,59/0,08 mm. We concluded that the tangential excision, for longitudinal melanonychia, provides an adequate material for histopathological diagnosis.
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