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There are large areas of tumor necrosis and prominent vascular/endothelial proliferation. Most tumor cells are pleomorphic with varying amounts of fibrillary cytoplasm. I believe this is sufficient for the diagnosis of WHO grade IV glioblastoma. Figures 2 and 3 show some tumor cells with perinuclear halos. Although this suggests oligodendrocytic differentiation, exactly how much of tumor areas look like this would determine whether to use the diagnostic qualifier of "WHO grade IV glioblastoma with an oligodendroglioma component," which has a better prognosis than a usual glioblastoma. I don't think this is WHO grade III anaplastic oligodendroglioma because of astrocytic features in most photos uploaded.
聞道有先後,術業有專攻
liangjinjun 离线