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混合腺神经内分泌癌 ( mixed adenoneuroendocrine carcinoma, MANEC)的定义:
表型上具有形成腺管的上皮细胞和神经内分泌细胞,且因为两者都是恶性而可定义为癌。偶有鳞癌成分但少见。一般人为的设定两种成分至少占肿瘤成分的30%以上才能诊断为混合癌。仅在腺癌中发现少量免疫组化阳性的神经内分泌细胞则不足以诊断混合癌。
IHC results:
[Final Diagnosis]
Stomach, body, subtotal gastrectomy:
Mixed adenoneuroendocrine carcinoma, with squamous cell carcinoma (T4aN3aM0)
Adenocarcinoma, moderately differentiated (35%)
+ large cell neuroendocrine carcinoma (45%)
+ squamous cell carcinoma, well differentiated (20%)
治疗:手术后诊断为三期,进行了Cisplantin (1/3wks)+ Daily TS-1(tegafur)