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liguoxia71 离线
Immunohistochemical expression
mesothelioma
rarely positive in pulmonary and laryngeal squamous cell carcinoma
pancreatic islet cell tumour
hepatocellular carcinoma
follicular and papillary thyroid carcinoma
neuroblastoma
ganglioglioma
oligodendroglioma
glioblastoma multiforme
retinoblastoma
natural killer cells and a subset of T-lymphocytes
osteoblasts9
The following are negative for CD 56:nasopharyngeal carcinoma,
colonic carcinoma,melanoma,meningioma,hairy cell leukaemia,Ewing's sarcoma
CK20 is useful in the differential diagnosis of small cell carcinomas:
Site of small cell carcinoma (Number of cases) |
Number showing CK20 reactivity |
Number showing CAM 5.2 or MNF-16 staining |
98% (33/34, 23/234) |
88% (30/34) | |
Lung |
1% (1/37, 0/524) |
35% (13/37) |
3/5 |
3/5 | |
Alimentary tract |
0/9, 0/154 |
4/9 |
Upper aerodigestive tract |
0/5 |
3/5 |
Larynx |
0/9 |
2/9 |
Pancreas |
0/1 |
0/1 |
Thymus |
0/3 |
1/3 |
Breast |
0/2 |
0/2 |
Kidney |
0/1 |
0/1 |
Urinary bladder |
0/2, 0/34 |
0/2 |
Prostate |
0/3, 0/34 |
0/3 |
Uterine corpus |
0/1 |
0/1 |
Uterine cervix |
1/11 |
1/11 |
liguoxia71 离线
"有时候小细胞癌不表达CK,并不是抗体的问题,正常的角化上皮不出来,小细胞癌CK的阳性率具体多少我不太清楚了,您可以做CK8/18,其在小细胞癌中阳性率还可以,CK5/6就不行,神经内分泌方面有时候也不是全部表达,经常会碰到CGA或者SYN阴性的情况,有时候甚至两者都阴性,这时候您可以选用CD56 ”。
那么,CK阴性并不能排除小细胞癌。可以做CK8/18、CD56(为什么不是CD57?)证实是否是小细胞癌?学习了,谢谢!
另外,CK20,俺只知道用以标记:胃肠道上皮、泌尿上皮、Merkel细胞等,不知对于小细胞癌的诊断的作用?哪位老师能讲解一下?谢谢!