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panzenggang 离线
Beautiful slides.
The architecture of lymph node is partially affaced with marked interfollicular expansion and focal residual lymphoid follicles. The interfollicular areas consists of a mixed population of small lymphocytes, largers transformed lymphocytes, histiocytes/largerhans cells, eosinophils and high-endothelial venules. Overall, there is obvious morphologic evidence of lymphoma, but I totally agree with Dr. Arthus; basic immunostainis are necessary to rule out a T- or B-cell lymphoma. Other differential diagnosis also includes:
1). Infectious process. EBV, CMV or other virus.
2). Medication or vaccination.
3). Please do CD30 to rule out Hodgkin lymphoma or other sneakLy ALCL/PTCL.
4). Look carefully for myeloid sarcoma, which I think it is very unlikely in the case.
5). If all obove are ruled out, maybe consider doing IgG and IgG4 to rule out "IgG4 associated lymphadenopathy, paracortical expansion variant".
panzenggang 离线
Beautiful slides.
The architecture of lymph node is partially affaced with marked interfollicular expansion and focal residual lymphoid follicles. The interfollicular areas consists of a mixed population of small lymphocytes, largers transformed lymphocytes, histiocytes/largerhans cells, eosinophils and high-endothelial venules. Overall, there is obvious morphologic evidence of lymphoma, but I totally agree with Dr. Arthus; basic immunostainis are necessary to rule out a T- or B-cell lymphoma. Other differential diagnosis also includes:
1). Infectious process. EBV, CMV or other virus.
2). Medication or vaccination.
3). Please do CD30 to rule out Hodgkin lymphoma or other sneakLy ALCL/PTCL.
4). Look carefully for myeloid sarcoma, which I think it is very unlikely in the case.
5). If all obove are ruled out, maybe consider doing IgG and IgG4 to rule out "IgG4 associated lymphadenopathy, paracortical expansion variant".