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高级别尿路上皮癌,部分为乳头状癌,浸润至固有层(至少PT1期);小活检标本最好这么报。如果可能的话,量一下浸润灶的最大深度。研究表明,在活检标本中,从粘膜基底膜开始测量浸润灶的最大深度,使用1.5mm的临界值进行PT1亚分期对于预测全切膀胱标本的尿路上皮癌分期具有重要的预测作用。1.5mm的浸润深度,预测进展期膀胱癌(PT2期)的敏感性和特异性分别为81%及83%,阳性和阴性预测值分别为95%及56%。TUR标本中,浸润深度超过1.5mm的膀胱癌95%在全切膀胱中为进展期癌(PT2)。
Substaging of pT1 carcinoma based on ocular micrometer measurement of tumor invasion is an
alternate strategy to provide information for the management of pT1 cancer . Using an ocular micrometer to measure the depth of invasion from the mucosal basement membrane,investigators have found a significant correlation between depth of invasion in the biopsy specimens and final pathological stage at cystectomy. A 1.5mm depth of invasion predicted advanced-stage bladder carcinoma at cystectomy with a sensitivity of 81%, a specificity of 83%, and positive and negative predictive values of 95 and 56%, respectively.Ninety-five percent of patients with the depth of invasion >1.5mm at TUR specimens have advanced stage (pT2) bladder carcinoma at cystectomy.
可参考文献:
Cheng L,Montironi R,et al.Staging and reporting of urothelial carcinoma of the urinary bladder.Modern Pathology (2009) 22, S70–S95.
高级别尿路上皮癌,部分为乳头状癌,浸润至固有层(至少PT1期);小活检标本最好这么报。如果可能的话,量一下浸润灶的最大深度。研究表明,在活检标本中,从粘膜基底膜开始测量浸润灶的最大深度,使用1.5mm的临界值进行PT1亚分期对于预测全切膀胱标本的尿路上皮癌分期具有重要的预测作用。1.5mm的浸润深度,预测进展期膀胱癌(PT2期)的敏感性和特异性分别为81%及83%,阳性和阴性预测值分别为95%及56%。TUR标本中,浸润深度超过1.5mm的膀胱癌95%在全切膀胱中为进展期癌(PT2)。
Substaging of pT1 carcinoma based on ocular micrometer measurement of tumor invasion is an
alternate strategy to provide information for the management of pT1 cancer . Using an ocular micrometer to measure the depth of invasion from the mucosal basement membrane,investigators have found a significant correlation between depth of invasion in the biopsy specimens and final pathological stage at cystectomy. A 1.5mm depth of invasion predicted advanced-stage bladder carcinoma at cystectomy with a sensitivity of 81%, a specificity of 83%, and positive and negative predictive values of 95 and 56%, respectively.Ninety-five percent of patients with the depth of invasion >1.5mm at TUR specimens have advanced stage (pT2) bladder carcinoma at cystectomy.
可参考文献:
Cheng L,Montironi R,et al.Staging and reporting of urothelial carcinoma of the urinary bladder.Modern Pathology (2009) 22, S70–S95.