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emilypeaker 离线
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Signet ring cell carcinoma is an epithelial malignancy characterized by thehistologic appearance of signet ring cells.
It is a form of adenocarcinoma,[1] (个人认为，既然印介比一般腺癌预后更差，是不是应该作为第一诊断，或者腺癌提都不用提)and it is most often found in the glandular cells of the stomach, but it may develop in other areas of the body [2]. Some cases (not all) are inherited, and these cases are often caused by mutations in the CDH1 gene [3].
[edit]Metastases
The pattern of metastases is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. In cases where gastric signet cell carcinoma metastasizes, it tends to spread to peritoneal metastases, lymphatic permeation of the lungs, and to the ovaries, creating Krukenberg tumors[4].
[edit]Histologic appearance
Main article: signet ring cell
Signet ring cells resemble signet rings because a large vacuole full of mucin displaces the nucleus to the periphery.
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yumaoqiu715 离线
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