MAP belongs to the surgical pathology

 DEPARTMENT OF PATHOLOGY DIVISIONS

Division of Molecular Anatomic Pathology

Yuri Nikiforov, M.D., Ph.D., Director

Division of Molecular Anatomic Pathology Web Site

The Division of Molecular Anatomic Pathology coordinates and provides molecular diagnostic service in anatomic pathology, primarily in solid tumors, and foster an academic environment devoted to enhancement of the molecular progress in anatomic pathology. Please visit our web site for full information on services and other activities provided by the Division and by Molecular Anatomic Pathology Laboratory.

HIGHLIGHTS

• Provides most advanced molecular testing in solid tumors, offering a large variety of molecular markers for diagnosis and predicting therapeutic response in tumors of brain, lung, colon, and many other organs.
• Offers to local and national clients a variety of unique molecular tests, such as the laboratory-developed mutational panel for cancer detection in thyroid nodules and double primary tumor test.
• Designs and introduces new molecular tests based on innovative technologies such as SNP array, gene expression array, and miRNA.
• Performs groundbreaking research in various areas of molecular diagnostics of solid tumors, basic mechanisms of carcinogenesis, and DNA repair.

Division of Molecular Anatomic Pathology Web Site

 List of Tests

Brain Tumors
Glioma Panel (deletion of 1p, 19q, p16, PTEN, TP53)
MGMT promoter methylation
IDH1 and IDH2 mutations

Colorectal Cancer
Microsatellite Instability (MSI) analysis
KRAS mutation
BRAF mutation

Lung Cancer
EGFR exon 19 and 21 mutation
KRAS mutation

Thyroid Cancer
Thyroid Panel: BRAF, NRAS, HRAS, KRAS, RET/PTC, PAX8/PPAR γ; mutations (for freshly collected FNA samples and frozen tissue)
Thyroid Panel: BRAF, NRAS, HRAS, and KRAS mutations by PCR and RET/PTC by FISH (for fixed FNA samples and FFPE tissue)
BRAF mutation
Thyroid LOH analysis, follicular cancer

Melanoma
BRAF mutations in exon 15

Other Tests
Parathyroid Panel, LOH analysis
Pancreatic Panel, LOH analysis & KRAS mutation
Liver Panel, LOH analysis
Appendicial Panel, LOH analysis & KRAS mutation
Double primary testing for tumor de novo vs. metastasis
Tissue identity testing

 Molecular Anatomic Pathology Division Faculty

Yuri Nikiforov, MD, PhD
Marina Nikiforova, MD
Rohit Bhargava, MD
Simion Chiosea, MD
Sanja Dacic, MD, PhD
Jon Davison, MD
Rajiv Dhir, MD
Alyssa Krasinskas, MD
William LaFramboise, PhD
Jianhua Luo, MD, PhD
Geoffrey Murdoch, MD, PhD
Michael Nalesnik, MD
Paul Ohori, MD
Anil Parwani, MD, PhD
Sarangarajan Ranganathan, MD
Uma Rao, MD
Raja Seethala, MD
Chenquan Zhao, MD

 The Division of Molecular Anatomic Pathology is part of the Department of Pathology at the University of Pittsburgh Medical Center (UPMC). Established in December, 2006, the Division provides and coordinates molecular diagnostic service in anatomic pathology at UPMC. The Division offers variety of molecular tests in the area of solid tumor diagnostics. The Division members work in close cooperation with anatomic pathologists and various clinical groups at the University of Pittsburgh Medical Center to provide and further develop the most advanced molecular anatomic pathology testing.

One of the important missions of the division is to foster an academic environment devoted to enhancement of the molecular progress in anatomic pathology and to support the research activities of the faculty, fellows, and residents in the department and the institution.

Another mission of the Division is to provide training in Molecular Anatomic Pathology for pathology fellows and residents, as well as for medical students. Elective rotations are available for pathology residents. Fellowship training opportunities are available for physicians who have completed and accredited residency in Anatomic Pathology. The program focuses on providing fellows and residents with knowledge necessary to integrate most recent advances in molecular anatomic pathology into routine diagnostic pathology practice.

 http://path.upmc.edu/divisions/map/index.htm