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1.神经鞘瘤--富于细胞性神经鞘瘤-恶性外周神经鞘瘤是一个怎样的过度？
2.富于细胞性神经鞘瘤诊断标准的把握：核分裂像，细胞的丰富程度，坏死，包膜的有无等，如何掌握？如果达不到，我们又如何面对？
3.核分裂像，细胞的丰富程度，坏死，包膜的有无，S-100的表达方式（局灶还是弥漫）在三种诊断标准上的把握?
4.上皮样恶性外周神经鞘瘤能否起源于神经鞘瘤？
5.神经母细胞性神经鞘瘤附属低度恶性范畴还是良性范畴？介于富于细胞性神经鞘瘤和恶性外周神经鞘瘤中间的过度，我们在发报告时如何应对？
6.Smarcb1蛋白的缺失在其鉴别诊断中的作用？
Epithelioid Malignant Peripheral Nerve Sheath Tumor Arising in a Schwannoma, in a Patient With “Neuroblastoma-like” Schwannomatosis and a Novel Germline SMARCB1 Mutation  (Am J Surg Pathol 2012;36:154–160)Abstract: Epithelioid malignant peripheral nerve sheath tumors
arising in preexisting schwannomas are extremely rare. We
report an unusual example occurring in a patient with multiple
schwannomas (schwannomatosis), all but 1 of which showed
“neuroblastoma-like” histology. By immunohistochemistry,
both the epithelioid malignant peripheral nerve sheath tumor
and the schwannomas showed a complete loss of the Smarcb1
protein. Subsequent genetic evaluation revealed the presence of
a novel germline mutation in the SMARCB1/INI1 gene in the
patient and in 3 of her children, 2 of whom were diagnosed with
atypical teratoid/rhabdoid tumors of the brain.