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liuxing2011 离线
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这篇2010年的文献CK7可以表达于原发的鳞状细胞癌，呵呵，本例的有限心态学图片感觉好像还是倾向为鳞状细胞团块。你的发现是很有价值的。
J Cutan Pathol. 2010 Sep;37(9):966-72. Epub 2010 May 26.
CK7 expression in primary cutaneous squamous cell carcinoma.
Source
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pulitzem@mskcc.org
Abstract
AIM:
To evaluate cytokeratin 7 (CK7) immunoreactivity in invasive primary cutaneous squamous cell carcinomas (SCCs).
METHODS:
Twenty-seven primary cutaneous SCCs from 25 patients were evaluated for tumor grade using hematoxylin and eosin-stained slides and for percentage and intensity of immunoreactivity for CK7. All cases exhibited features of SCC with an in situ component. No glandular or tubular differentiation was present. Staining intensity was graded on a scale of 0-3, with 0 indicating no reaction. Of immunoreactive cases, percentage of tumor staining and distribution of immunoreactivity was documented.
RESULTS:
Six of 27 SCCs (22%) exhibited immunostaining for CK7. Of those cases, three were poorly differentiated, exhibiting 2 to 3+ intensity in 5-15% of cells. Two were poorly differentiated, with 2 to 3+ intensity in 30-60% of cells. The remaining immunoreactive tumor was moderately differentiated, with 1+ intensity and 5% staining in an area of microinvasion.
CONCLUSION:
A subset of cutaneous SCCs, in particular, poorly differentiated tumors低分化肿瘤, may show focal-to-partial immunoreactivity for CK7可以出现部分或局灶的CK7表达. This is important to bear in mind when immunohistochemistry is used to distinguish SCC from simulants, such as porocarcinoma, or other adnexal carcinomas with squamous metaplasia在区分汗腺来源或是其他皮肤附属器来源肿瘤伴有的鳞状细胞化生时需要特别注意.
呵呵，楼主要是能收集一些其他部位如宫颈、食道、口腔、肺的癌做做CK7，看看表达的pattern，就可以发一篇sci的文章了，呵呵
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redsnow007 离线
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