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纤维瘤、Brenner瘤和卵泡膜瘤大体上几乎不能区分。但镜下Brenner瘤除了纤维组织外,还有上皮成分。纤维瘤和卵泡膜瘤二者往往不太好区分。本例图片不甚清晰,但可看出来胶原很多,没有明确的卵泡膜样的细胞(胞质宽、染色淡、界限不清)。大体上也没有泛黄色。所以考虑是个纤维瘤。
Common; benign; arise after puberty
40% of tumors >
Gross: mean
Micro:
closely packed spindle cells in “feather-stitched” or storiform pattern;
may have hyaline bands and edema; no atypia
Positive stains: CD56 (not specific), WT1, ER-beta, PR, variable smooth muscle actin, occasional S100 and CD34 (Am J Surg Pathol 2008;32:884)
Molecular: trisomy 12
DD:
1. Cellular fibroma (up to 3 mitoses/10 high power fields),
2. Fibrosarcoma (4+ mitoses/10 HPF), massive edema,
3. Fibromatosis,
4. thecoma,
5. Brenner tumor,
6. Krukenberg tumor
References: Am J Surg Pathol 2002;26:1477