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女,25岁,甲状腺左叶腺瘤,另左叶上极见一灰白质硬区,范围0.8*0.6cm
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甲状腺乳头状癌(PTC)的定义:滤泡细胞分化的证据,典型者有乳头和滤泡结构,核的特征:毛玻璃样或苍白;核增大;形状不规则;深的核沟;假包涵体。
其主要诊断标准:
1.核呈卵圆形,而不是圆形
2.核拥挤重叠("上窜下跳",无极性)
3.核染色质苍白或透明(直至毛玻璃样),或明显核沟
4.砂粒体(鉴别:胶质钙化)
其次要诊断标准:
1.流产型乳头
2.大部分滤泡拉长或形状不规则
3.胶质深染
4.核内假包涵体
5.滤泡腔内多核组织细胞
诊断PTC的严格标准:≥3个主要标准,或2个主要标准加≥4个次要标准
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甲状腺乳头状癌。
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