At lower power view, differential diagnosis includes neoplasm and inflammatory/granulomatous changes.
At higher power view, the lesion is favored a neoplasm. A pilot panel of IHC may be helpful. CD45 and cytokeratin should be done to assess the nature of the atypical cells, lymphocytic or epithelial. Others, like melanoma, should be also considered, if the initially IHC stains are negative. Certainly, clinical correlation (including endoscopically appearance) is important.
At lower power view, differential diagnosis includes neoplasm and inflammatory/granulomatous changes.
At higher power view, the lesion is favored a neoplasm. A pilot panel of IHC may be helpful. CD45 and cytokeratin should be done to assess the nature of the atypical cells, lymphocytic or epithelial. Others, like melanoma, should be also considered, if the initially IHC stains are negative. Certainly, clinical correlation (including endoscopically appearance) is important.