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- B216作子宫肌瘤切除的病人，发现宫颈病变
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| Case (1) | 宫颈疾病 | 性别： | 女 | 年龄： | 45岁 |
| 标本名称： | 全子宫 | ||||
| 简要病史： | 多发性子宫肌瘤 | ||||
| 肉眼检查： | 小块宫颈显得粗糙一些 | ||||
标签：宫颈 腺鳞癌
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本帖最后由 于 2007-10-18 20:47:00 编辑
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宫颈腺鳞癌及其讨论
| 以下是引用mjma在2007-10-10 11:28:00的发言： There is cytologic atypia in those few loosely detached cells in the lumen or on the surface of endocervical gland with reserve cell hyperplasia or immature squamous metaplasia. I would be careful in determining the clinical significance of these atypical cells. They may represent glandular or squamous epithelial dysplasia. p16 and p53 immunohistochemical stains may help. The entire uterus has been removed, so this is literally an academic question for now (unless simultaneous or follow-up Pap smear shows vaginal squamous epithelial dysplasia). |
I essentially agree with Dr. Ma's interpretation. P16 immunostain can rule out any significant HPV-related dysplasia.
To answer Chengbei's question below, this is ABSOLUTELY NOT carcinoma in situ.
- 不坠青云之志，长怀赤子之心
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本帖最后由 于 2007-10-11 19:51:00 编辑
There is cytologic atypia in those few loosely detached cells in the lumen or on the surface of endocervical gland with reserve cell hyperplasia or immature squamous metaplasia. I would be careful in determining the clinical significance of these atypical cells. They may represent glandular or squamous epithelial dysplasia. p16 and p53 immunohistochemical stains may help. The entire uterus has been removed, so this is literally an academic question for now (unless simultaneous or follow-up Pap smear shows vaginal squamous epithelial dysplasia).
宫颈腺腔内少数松散、脱落的细胞或腺表面的细胞有不典型性，伴储备细胞增生或不成熟鳞化。我会谨慎地解释这些不典型细胞的临床意义。它们可能是腺或鳞上皮的异型增生。p16和p53染色可能有帮助。既然已经切除了全子宫，那么只是学术上的讨论了（除非同时或随访的PAP涂片发现阴道鳞状细胞异型性）。 --abin译
聞道有先後,術業有專攻
