,哪位老师能翻译下吗，谢谢 
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| 名称： | |
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- 乳腺腺病边缘小病灶（TTF-1阳性表达的乳腺癌-新视点）
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| 姓 名： | ××× | 性别： | 女 | 年龄： | 43岁 |
| 标本名称： | |||||
| 简要病史： | 发现左乳肿块半年 手术所见：外下象限可触及约3*3厘米大小肿块，质中，界欠清，无压痛 临床诊断：左乳肿块 | ||||
| 肉眼检查： | 5*4* | ||||
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本帖最后由 于 2010-12-06 18:32:00 编辑
×参考诊断
浸润性导管癌3级，（ER/PR/HER2 三阴乳腺癌）。注：TTF-1阳性。
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谢谢赵老师！
以上英文文摘中文大意如下：
TTF-1免疫标记常被用来帮助判断转移癌源自何处。最常见其在甲状腺和肺来源的癌中表达。进而，想象中只要癌中阳性表达TTF-1，就除外乳腺起源的可能性。作者在其会诊病例中曾遇到过4例表达TTF-1的浸润性导管癌（经临床表现加上免疫表型特征所证实），标记显示肿瘤细胞确实表达TTF-1。然而，乳腺癌所见TTF-1表达的阳性率目前尚不清楚。为此，作者对546例原发性乳腺癌进行了TTF-1免疫标记（这些病例常规做了ER、PR和HER-2的标记检测）。TTF-1标记在核中呈阳性着色，便视为阳性病例。结果证明其中13例（2.4%）为TTF-1阳性表达病例。阳性表达的病例中，呈局灶性弱表达至弥漫性强表达，并在浸润癌和原位癌中均可表达。结论：有少数乳腺癌病例表达TTF-1。因此，一旦癌中检测到TTF-1阳性标记，不能擅自排除乳腺源发癌的可能性。
- 王军臣
The paper in AJSP this month
Am J Surg Pathol. 2010 Dec;34(12):1881-5.
Thyroid transcription factor-1 expression in breast carcinomas.
Robens J, Goldstein L, Gown AM, Schnitt SJ.
*Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA †PhenoPath Laboratories, Seattle, WA.
Abstract
Immunostaining for thyroid transcription factor-1 (TTF-1) is frequently used to help assess the site of origin of metastatic carcinomas. TTF-1 expression is most frequently seen in carcinomas of thyroid and lung origin. Furthermore, it has been assumed that the expression of TTF-1 in a carcinoma excludes the possibility of a breast origin. We have recently encountered in our consultation practice 4 cases of invasive breast carcinoma (confirmed by clinical findings and other immunophenotypic features) that showed unequivocal tumor cell expression of TTF-1. However, the frequency with which TTF-1 expression is observed in breast carcinomas is unknown. To address this, we carried out immunostaining for TTF-1 on 546 primary breast carcinomas submitted for routine estrogen receptor, progesterone receptor, and/or HER2 testing. Cases were considered TTF-1 positive if they showed any nuclear staining for this marker. TTF-1 expression was identified in 13 cases (2.4%). Expression varied from focal and weak to diffuse and strong and was seen in both invasive and in situ components. We conclude that a small proportion of breast carcinomas show TTF-1 expression. Therefore, the presence of TTF-1 immunoreactivity in a carcinoma cannot by itself be used to exclude the possibility of a breast origin.
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本帖最后由 于 2010-11-27 21:54:00 编辑
| 以下是引用xljin8在2010-11-26 16:53:00的发言： 1. Appl Immunohistochem Mol Morphol. 2010 Mar;18(2):142-9.Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in pulmonary and nonpulmonary primary tumors.
TTF-1有二珠单克隆抗体，二者的表达有些差异。但是本文作者的研究中乳腺癌均不表达TTF-1。 |
- xljin8
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本帖最后由 于 2010-11-27 21:52:00 编辑
| 以下是引用xljin8在2010-11-26 16:49:00的发言：
Case Report.Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ. Michael Christie1, Laura Chin-Lenn2, Monique M. Watts3, Alpha E. Tsui1, Malcolm R. Abstract: Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma of the breast with coexisting carcinomain situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid transcription factor-1 (TTF-1) by IHC. Expression of neuroendocrine markers and TTF-1 in the in situ component allowed a highly confident diagnosis of primary small cell carcinoma of the breast. To our knowledge there is only one previous report of TTF-1 expressing in situ carcinoma associated with a primary SmCC of the breast.
根据此文献复习已有2例乳腺原发性小细胞癌表达TTF-1。本例报道中的小细胞癌和导管原位癌二种成分均表达TTF-1。 |
- xljin8
