透明细胞癌

The different dx includes 透明细胞癌vs. 颗粒细胞瘤orSertoli-leydig细胞瘤based on above comment.

It should be easy to do some IHC: EMA, Inhibin, calretinin.

we are waiting for the result. thanks.

Why cannot you make dx for this case in your lab?

Clear cell adenocarcinoma -

tubular-cystic, or solid; papillary cores have prominent hyalinization; large tumor cells, some with nuclei that protrude into lumina (hobnail), clear cytoplasm (glycogen, mucin, fat); resembles mucinous tumor on frozen section

Positive stains:  keratin,  hepatocyte nuclear factor 1 beta

Negative stains: AFP, WT1, ER, usually GPC3

DD:

yolk sac tumor (AFP+, GPC3+) ,

Granulosa cell tumor-juvenile （inhibin, calretinin）VS CCC(older patients, diffuse hobnail cells, no follicles, no juvenile granulosa type cells)

 第一次传图的可见钉突细胞、扁平细胞、透明细胞，应该考虑透明细胞癌

第二次传图的那些巢状红染的细胞，需鉴别合并brener瘤的可能，但是从细胞形态看更多还是象透明细胞的

 考虑性索间质来源肿瘤

 静等结果！