依据HE更偏向考虑性索间质肿瘤，但给的病史病史和大体好像。。。

会诊的结果呢？等急了啊

Clear cell adenocarcinoma -

tubular-cystic, or solid; papillary cores have prominent hyalinization; large tumor cells, some with nuclei that protrude into lumina (hobnail), clear cytoplasm (glycogen, mucin, fat); resembles mucinous tumor on frozen section

Positive stains:  keratin,  hepatocyte nuclear factor 1 beta

Negative stains: AFP, WT1, ER, usually GPC3

DD:

yolk sac tumor (AFP+, GPC3+) ,

Granulosa cell tumor-juvenile （inhibin, calretinin）VS CCC(older patients, diffuse hobnail cells, no follicles, no juvenile granulosa type cells)

we are waiting for the result. thanks.

Why cannot you make dx for this case in your lab?

The different dx includes 透明细胞癌vs. 颗粒细胞瘤orSertoli-leydig细胞瘤based on above comment.

It should be easy to do some IHC: EMA, Inhibin, calretinin.