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- 罕见病理-2 胃母细胞瘤（Gastroblastoma）
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•参考文献：
Markku Miettinen, MD,* Nancy Dow, MD,w Jerzy Lasota, MD,* and Leslie H. Sobin, MDw .•A Distinctive Novel Epitheliomesenchymal Biphasic Tumorof the Stomach in Young Adults (‘‘Gastroblastoma’’)A Series of 3 Cases ;Am J Surg Pathol 2009;33:1370–1377
Differential Diagnosis
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Carcinosarcoma | |
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Young adults |
Generally older patients |
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Cytologically bland Indonent clinical course |
Malignant epithelial and stromal elements Very aggressive tumor with frequent metastasis |
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Gastric Synovial Sarcoma | |
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Components may be indistinct |
Components generally distinct |
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FISH negative for SS18 abnormalities |
FISH shows evidence of SS18 rearrangement |
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Mesothelioma | |
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Negative for CK5/6 and calretinin |
CK5/6 and calretinin positive |
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Not serosal based |
Based in serosa |
- Biphasic epitihelial-mesenchymal tumr of the stomach
- One report of three cases to date (Miettinen)
- Two components: mesenchymal and epithelial
- May be sharply or indistinctly demarcated
- Diffuse sheets of uniform oval to spindled cells
- Clusters and cords of epithelioid cells
- Occasional small gland formation by epithelioid cells in a field of spindled cells
- Mitotic rates observed: 0, 4, 30 / 50 hpf
- All cases to date in young adults
Robert V Rouse MD rouse@stanford.edu
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342Original posting : 2/4/10
胃母细胞瘤（gastroblastoma）。
Definition
