44y female with 1.5cm breast mass detected on annual mammogram
女，44岁，每年一次的乳腺影像学筛查发现1.5cm乳房肿块。粗针穿刺。

下2图为切片全貌。

学习了。谢谢！

谢谢！学习了。

谢谢唐平老师，谢谢abin老师！

 唐平教授提供一篇文献，摘要：

Prognostic Significance of
Micropapillary Pattern in Pure
Mucinous Carcinoma of the Breast
Amanjit Bal, MD, DNB, Kusum Joshi, MD, MAMS, PhD, FICPath,
Suresh Chander Sharma, MD, Ashim Das, MD, FRCPath,
Alka Verma, MSc, MLT, and Jai Dev Wig, MS, FRCS, FAMS

    Breast carcinoma with micropapillary architecture is associated with aggressive behavior. Similar micropapillary pattern in pure mucinous carcinoma has been noticed and has been shown to convey poor prognosis. In this study 17 cases of pure mucinous carcinoma of the breast seen during a 10-year period have been reviewed, with special reference to micropapillary pattern. Diffuse micropapillary pattern was seen in 6 of 17 cases of mucinous carcinoma of the breast and demonstrated reverse polarity immunostaining pattern with “Epithelial Membrane Antigen.” In all cases, the tumor cells showed grade I morphology, and no lymph node metastases were noticed. All the tumors except 1 expressed strong estrogen and progesterone receptor expression, however, all the cases were negative for Her-2/neu expression. In this present study, mucinous carcinomas with micropapillary pattern showed a low nuclear grade, higher incidence of hormone receptor positivity, and lower incidence of Her-2/neu similar to mucinous carcinomas without micropapillary pattern, thus explaining their indolent behavior.

 谢谢唐平教授简要点评！

翻译如下：

此例病变的组织学表现兼有粘液样和微乳头状特征，粘液和极性倒置的特征均容易识别。包括我们，最近很多人称之为粘液癌伴微乳头状特征。也有人称为浸润性微乳头状癌的粘液样亚型。不管采取何种命名，其预后比纯粘液癌差，但可能比浸润性微乳头状癌好。因此在诊断中注明这种特点具有重要意义。