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- 20100714-肾脏肿瘤
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本帖最后由 于 2010-07-15 20:48:00 编辑
学习：
本例肿瘤细胞的免疫表型为：CKpan（++），vimentin（+），CD10大部分细胞弱阳性散在强阳性细胞（+），P504s（+/-）。免疫表型符合肾源性恶性肿瘤，命名学习明月老师的意见。
问题：
P504s的弱阳性表达，判定为阴性还是弥漫弱阳性？
附文献片断提示P504s可在肾源性肿瘤中表达，请参考。
Original Article
Modern Pathology (2004) 17, 1180–1190, advance online publication, 18 June 2004; doi:10.1038/modpathol.3800197
Diagnostic utility of a p63/
-methyl-CoA-racemase (p504s) cocktail in atypical foci in the prostate
More recently, AMACR, a cytoplasmic protein recently identified by cDNA library subtraction in conjunction with high-output microarray analysis of prostatic carcinoma,6, 23 has been considered as a marker that is substantially upregulated in prostate cancer. AMACR overexpression has been detected in many human tumors such as colon and mammary tumors, malignant melanomas and papillary renal carcinomas.24, 25, 26 AMACR is known to be involved in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives.27, 28 AMACR has been located in peroxisomes and mitochondria and in human cells, and expression of the enzyme is strongly expressed in normal liver and kidney cells.29 The racemic mixtures of branched fatty acids and fatty acid derivatives must first be converted by AMACR into peroxisomes, and mitochondria into (S) isomers, before undergoing beta-oxidation.28 Mitochondrial beta-oxidation of fatty acids donates electrons to the respiratory chain coupled with phosphorylation of ADP to ATP. Peroxisomes transform branched-chain fatty acids by acyl-CoA oxidase with the production of oxidized substrate and hydroxide hydrogen.27, 28
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本帖最后由 于 2010-07-15 21:53:00 编辑
| 以下是引用96298在2010-7-15 16:14:00的发言： Dr.96298 问“透明肾细胞癌 4级，肉瘤样癌那个好？”
非常好的问题！ 实际上您提问的透明细胞癌4级和肉瘤样肾细胞癌是二个不同的概念。 透明细胞癌4级是指透明细胞癌中透明细胞Fuhrman核分级4级， 而不指组织学分级和形态学变异。因此透明细胞癌4级不等同于肉瘤样肾细胞癌（肾细胞癌，肉瘤样型） 肉瘤样肾细胞癌是指肾细胞癌中有肉瘤样的形态区域，其至少大于等于1个低倍视野（4X）。而其中的肾细胞癌可以是透明细胞癌、乳头状癌、嫌色细胞癌、集合管癌、未分类癌。
谢谢您的提问！ 供参考。 |
- xljin8
