移植肾疑为急性T细胞介导性排斥反应(suspicious of T cell-mediated rejection,Banff2007 Schema,i1,t1,g0,v0,ci0;ct0,cg2,cv1),同时可见2支细小动脉内膜轻度增生增厚,提示有早期轻微慢性T细胞介导性排斥反应表现;另少数肾小管上皮细胞明显肿胀、水变性,其中可见少许细小等大空泡,结合部分肾小球呈轻微缺血状外观,提示轻微CNI类免疫抑制剂毒性损伤可能。
移植肾疑为急性T细胞介导性排斥反应(suspicious of T cell-mediated rejection,Banff2007 Schema,i1,t1,g0,v0,ci0;ct0,cg2,cv1),同时可见2支细小动脉内膜轻度增生增厚,提示有早期轻微慢性T细胞介导性排斥反应表现;另少数肾小管上皮细胞明显肿胀、水变性,其中可见少许细小等大空泡,结合部分肾小球呈轻微缺血状外观,提示轻微CNI类免疫抑制剂毒性损伤可能。
肾小管空泡变性 and arterial smooth muscle 空泡变性 (photo 4) are highly suggestive of acute drug toxicity. The interstitial mononuclear cell infiltration and tubulitis suggest acute cellular rejection. But these two conditions do not often occur at the same time. Let us know your thought.
The focal positive C4d should be interpreted along with the result of donor specific antibody (DSA). Without DSA results, it is suggestive of, but not diagnostic for, the chronic
active antibody-mediated rejection.
肾小管空泡变性 and arterial smooth muscle 空泡变性 (photo 4) are highly suggestive of acute drug toxicity. The interstitial mononuclear cell infiltration and tubulitis suggest acute cellular rejection. But these two conditions do not often occur at the same time. Let us know your thought.
The focal positive C4d should be interpreted along with the result of donor specific antibody (DSA). Without DSA results, it is suggestive of, but not diagnostic for, the chronic
active antibody-mediated rejection.