These cells look like signet ring cells.  But two things are holding me off: 1) signet ring cell carcinoma usually presents as infiltrating tumor cells causing diffuse thickening of gastric walls (所谓皮革胃），not as distinct small polyps. 2)adjcent glands and surface epithelium are perfectly benign/unremarkable, not even the mildest atypia/dysplasia.

I have seen cases of abundant foamy histiocytes accumulation in stomach presented as polyps, simillar to xantholesma in eyelides, it is called xanthomatous gastritis.  I would do pan CK and CD68 to differentiate these two entirely different diseases.

译:这些细胞看上去象印戒细胞.但两件事件让我不放心:1)印戒细胞癌通常表现为浸润性肿瘤细胞,故引起胃壁弥漫性增厚(所谓皮革胃),不表现为明显的小息肉.2)附近的腺体和表面的上皮表现为很非常的良性/无明显的异型,甚至也无轻微的不典型增生/异型增生.

我已看过大量泡沫样组织细胞积聚呈息肉改变的病例,相似于眼睑的黄色瘤,这叫做黄色肉芽肿型胃炎.我将做广谱的CK和CD68来区别这二者完全不同的疾病.

THANKS FOR YOUR BRILLIANT VIEW!