中国女性乳腺癌分子亚型的特点和预后

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中国女性乳腺癌分子亚型的特点和预后

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姓名：	×××	性别：	年龄：
标本名称：
简要病史：
肉眼检查：

国外对乳腺癌分子分型已经有不少大样本研究，本研究是基于中国人群的大样本（1820例）的回顾性研究，这些乳腺癌病例按免疫组化ER/PR/HER2表达情况分为不同的分子亚型，该研究评估了这些分子亚型的临床病理特点和预后情况。
  该研究发现，腺腔A型在头胎足月产年龄较大的女性中最常见；基底细胞亚型倾向于更早的发病年龄、更高的淋巴结阳性率、更常见的乳腺癌家族史、更大的肿瘤体积、更高的肿瘤级别、更高绝经前发病率、以及更早的月经初潮；基底细胞亚型和HER2亚型本身是预后差因素；家族史仅在基底细胞亚型中证明为预后差的独立因素。
  这个基于中国人群的大样本研究，为我们揭示了中国女性乳腺癌分子亚型的特点，期待将来有更深入和具体的新发现。
Journal of Surgical Oncology 2009;100:89–94
Characteristics and Prognosis for Molecular Breast Cancer Subtypes in Chinese Women
JING ZHAO, MD,Department of Breast Cancer, Cancer Institute & Hospital, Tian Jin Medical University
  Background: Breast cancer is regarded as a heterogeneous disease with four molecular subtypes. However, the clinicopathological characteristics among the different subtypes have not been studied in Chinese demographic. This study clariﬁes the prevalence and clinicopathological features of each subtype and investigates the independent prognosis factors in the Chinese population.
Methods: A retrospective review of 1,820 Chinese breast cancer women were classiﬁed into different molecular subtypes based on the IHC-based deﬁnitions for ER, PR, and HER-2/neu to evaluate the clinicopathological features and prognosis.
Results: Luminal A subtype was the most prevalent with the oldest median age at ﬁrst full-term birth. The basal cell-like subtype was associated with early onset, higher percentage of node positivity, family history of breast cancer, increased tumor size, advanced tumor grade, higher prevalence in the premenopausal group, and the earlier age at menarche. Univariate and multivariate analysis of OS and RFS identiﬁed the basal cell-like and HER-2/neu subtypes as negative prognostic factors. A family history was an independent predictor of shorter RFS and OS in only the basal cell-like subtype.
Conclusions: The basal cell-like subtype is associated with a poor prognosis and a family history was a negative predictor in the basal cell-like subtype.

Characteristics and Prognosis for Molecular.pdf
(2009-09-05 23:22:28, Size: 119 KB, Downloads: 1)

姓名：	×××	性别：	年龄：
标本名称：
简要病史：
肉眼检查：

国外对乳腺癌分子分型已经有不少大样本研究，本研究是基于中国人群的大样本（1820例）的回顾性研究，这些乳腺癌病例按免疫组化ER/PR/HER2表达情况分为不同的分子亚型，该研究评估了这些分子亚型的临床病理特点和预后情况。
  该研究发现，腺腔A型在头胎足月产年龄较大的女性中最常见；基底细胞亚型倾向于更早的发病年龄、更高的淋巴结阳性率、更常见的乳腺癌家族史、更大的肿瘤体积、更高的肿瘤级别、更高绝经前发病率、以及更早的月经初潮；基底细胞亚型和HER2亚型本身是预后差因素；家族史仅在基底细胞亚型中证明为预后差的独立因素。
  这个基于中国人群的大样本研究，为我们揭示了中国女性乳腺癌分子亚型的特点，期待将来有更深入和具体的新发现。
Journal of Surgical Oncology 2009;100:89–94
Characteristics and Prognosis for Molecular Breast Cancer Subtypes in Chinese Women
JING ZHAO, MD,Department of Breast Cancer, Cancer Institute & Hospital, Tian Jin Medical University
  Background: Breast cancer is regarded as a heterogeneous disease with four molecular subtypes. However, the clinicopathological characteristics among the different subtypes have not been studied in Chinese demographic. This study clariﬁes the prevalence and clinicopathological features of each subtype and investigates the independent prognosis factors in the Chinese population.
Methods: A retrospective review of 1,820 Chinese breast cancer women were classiﬁed into different molecular subtypes based on the IHC-based deﬁnitions for ER, PR, and HER-2/neu to evaluate the clinicopathological features and prognosis.
Results: Luminal A subtype was the most prevalent with the oldest median age at ﬁrst full-term birth. The basal cell-like subtype was associated with early onset, higher percentage of node positivity, family history of breast cancer, increased tumor size, advanced tumor grade, higher prevalence in the premenopausal group, and the earlier age at menarche. Univariate and multivariate analysis of OS and RFS identiﬁed the basal cell-like and HER-2/neu subtypes as negative prognostic factors. A family history was an independent predictor of shorter RFS and OS in only the basal cell-like subtype.
Conclusions: The basal cell-like subtype is associated with a poor prognosis and a family history was a negative predictor in the basal cell-like subtype.