本帖最后由 于 2007-01-28 09:40:00 编辑
以下是引用上善若水 在2006-10-19 22:21:00的发言：
软组织黏液样软骨肉瘤（软骨样肉瘤）。 |
同意，主要和脊索瘤、副脊索瘤鉴别，以下是鉴别点：
•（1）parachordoma has more architectural and cellular heterogeneity. It shows a curious blending of the predominant epithelioid cell with immature spindle cells and small, glomoid rounded cells.
• （2）Spindled areas in extraskeletal myxoid chondrosarcoma are quite unusual, whereas those encountered in chordoma are typically in high-grade, dedifferentiated tumors.
•（3）Neither chordoma nor extraskeletal myxoid chondrosarcoma possesses the small cell or glomoid component seen in parachordoma.
•（4） The matrix within parachordoma varies from myxoid to hyaline and contains a high concentration of hylauronic acid, as evidenced by reduction of Alcian blue staining after hyaluronidase predigestion. In contrast, the matrices of chordoma and extraskeletal myxoid chondrosarcoma, which appear uniformly myxoid, retain their Alcian blue positivity after enzymatic predigestion with hyaluronidase.
（5）parachordoma are almost always positive for CK8/18, EMA, S-100 protein, type IV collagen, and vimentin. In contrast, we did not find any case of extraskeletal myxoid chondrosarcoma to be positive for CK 8/18.
学习shiyhuaiy老师的讲解并试译如下：
同意“软组织黏液样软骨肉瘤（软骨样肉瘤）。”主要和脊索瘤、副脊索瘤鉴别，以下是鉴别点：
（1）副脊索瘤有更丰富的结构、细胞异质性。它显示上皮样细胞为主的、与不成熟梭形细胞和小的血管球状样圆形细胞的奇怪的混杂。
（2）骨外粘液样软骨肉瘤的梭形区域是非常少见的，而中存在这些区域的脊索瘤典型地为高级别、去分化肿瘤。
（3）脊索瘤或骨外粘液样软骨肉瘤都没有副脊索瘤中所见的小细胞或血管球状结构。
（4）副脊索瘤内的基质可出现从粘液样到透明变性的变化，含高浓度的透明质酸，可作透明质酸酶预消化后AB染色变少而证实。相反，脊索瘤和骨外粘液样软骨肉瘤的基质呈均一的粘液样，透明质酸酶预消化后AB染色仍保持阳性。
以下是引用上善若水 在2006-10-19 22:21:00的发言：
软组织黏液样软骨肉瘤（软骨样肉瘤）。 |
同意，主要和脊索瘤、副脊索瘤鉴别，以下是鉴别点：
•（1）parachordoma has more architectural and cellular heterogeneity. It shows a curious blending of the predominant epithelioid cell with immature spindle cells and small, glomoid rounded cells.
• （2）Spindled areas in extraskeletal myxoid chondrosarcoma are quite unusual, whereas those encountered in chordoma are typically in high-grade, dedifferentiated tumors.
•（3）Neither chordoma nor extraskeletal myxoid chondrosarcoma possesses the small cell or glomoid component seen in parachordoma.
•（4） The matrix within parachordoma varies from myxoid to hyaline and contains a high concentration of hylauronic acid, as evidenced by reduction of Alcian blue staining after hyaluronidase predigestion. In contrast, the matrices of chordoma and extraskeletal myxoid chondrosarcoma, which appear uniformly myxoid, retain their Alcian blue positivity after enzymatic predigestion with hyaluronidase.
（5）parachordoma are almost always positive for CK8/18, EMA, S-100 protein, type IV collagen, and vimentin. In contrast, we did not find any case of extraskeletal myxoid chondrosarcoma to be positive for CK 8/18.
学习shiyhuaiy老师的讲解并试译如下：
同意“软组织黏液样软骨肉瘤（软骨样肉瘤）。”主要和脊索瘤、副脊索瘤鉴别，以下是鉴别点：
（1）副脊索瘤有更丰富的结构、细胞异质性。它显示上皮样细胞为主的、与不成熟梭形细胞和小的血管球状样圆形细胞的奇怪的混杂。
（2）骨外粘液样软骨肉瘤的梭形区域是非常少见的，而中存在这些区域的脊索瘤典型地为高级别、去分化肿瘤。
（3）脊索瘤或骨外粘液样软骨肉瘤都没有副脊索瘤中所见的小细胞或血管球状结构。
（4）副脊索瘤内的基质可出现从粘液样到透明变性的变化，含高浓度的透明质酸，可作透明质酸酶预消化后AB染色变少而证实。相反，脊索瘤和骨外粘液样软骨肉瘤的基质呈均一的粘液样，透明质酸酶预消化后AB染色仍保持阳性。
