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最新的一篇综述，写的还不错，如果大家感兴趣，我把全文发给大家，希望阅读后多参与讨论：
Sotiriou, C. and M. J. Piccart (2007). "Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?" Nat Rev Cancer 7(7): 545-53.
The advent of microarray technology has enabled scientists to simultaneously investigate the expression of thousands of genes. Gene-expression profiling studies have provided a molecular classification of breast cancer into clinically relevant subtypes, new tools to predict disease recurrence and response to different treatments, and new insights into various oncogenic pathways and the process of metastatic progression. Here we describe the state of the art of gene-expression studies in breast cancer, and consider both their current limitations and future promises. We also discuss the potential of molecular signatures to have an impact on individual breast cancer patient management, and ultimately to accelerate the transition between empirical and tailored medicine.
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- 吾表兄，年四十余。始从文，连考三年而不中。遂习武，练武场上发一矢，中鼓吏，逐之出。改学医，自撰一良方，服之，卒。
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