Figures 4-6 do not show any reactive lymphoid follicles, raising the suspicion for lymphoma. However, the other higher power figures show mainly small lymphocytes admixed with scattered larger cell. These certainly do not support high grade diffuse large B cell lymphoma or Hodgkin disease. As to what it is exactly, that is much harder to answer. You will need immunohistochemical stains to further study this case. If you happen to save some fresh tissue for flow cytometry, that's also of great value in cases like this.
Figures 4-6 do not show any reactive lymphoid follicles, raising the suspicion for lymphoma. However, the other higher power figures show mainly small lymphocytes admixed with scattered larger cell. These certainly do not support high grade diffuse large B cell lymphoma or Hodgkin disease. As to what it is exactly, that is much harder to answer. You will need immunohistochemical stains to further study this case. If you happen to save some fresh tissue for flow cytometry, that's also of great value in cases like this.
To me, the morphological features raise the possibility of EBV related extranodal NK/T cell lymphoma, nasal type if there is vascular damage and destruction. Nee to perform IPX. It is immpossible to diagnosis a lymphoid proliferation disease without IP and flow. Cytogenetic or molecular study (Ig H or TCR rearragment ) can be very useful in diffficult cases.
To me, the morphological features raise the possibility of EBV related extranodal NK/T cell lymphoma, nasal type if there is vascular damage and destruction. Nee to perform IPX. It is immpossible to diagnosis a lymphoid proliferation disease without IP and flow. Cytogenetic or molecular study (Ig H or TCR rearragment ) can be very useful in diffficult cases.