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聞道有先後,術業有專攻
Agree with above.
CSF should be quite hypocellular and contains only a few mononuclear cells. Even without reference cells, these cells apprear large even at 40X (we usually don't use oil lense for non-hematopathologic cases). My minimal diagnosis: highly atypical cells, consistent with metastatic carcinoma. With real slide, i may be able to push to: Positive for malignant cells, consistent with breast primary.
We usually don't do immunostains in CSF becaue CSF is always scanty in volume (several mililiter) and it is almost impossible to prepare a cell block. Not many places can do immunostains on direct smears or cytospin, you have to de-stain H&E and re-stain with the entire IHC protocol. Cells may fall off the slides.