Figure 1 has a large cell with atypical nucleus, and Figures 7-8 show mild hypercellularity. The most worrisome is Figures 16-17 that show several Ki67-immunoreactive cells. This is a difficult case to diagnose. If this is a biopsy, I suggest that pre- and post-biopsy MRI images be compared to see if one can identify where biopsy was at. It is possible that the biopsied tissue represents peripheral edge of a glioma. If this is a resection specimen, then MRI images need to be looked at carefully before making any judgement.
Figure 1 has a large cell with atypical nucleus, and Figures 7-8 show mild hypercellularity. The most worrisome is Figures 16-17 that show several Ki67-immunoreactive cells. This is a difficult case to diagnose. If this is a biopsy, I suggest that pre- and post-biopsy MRI images be compared to see if one can identify where biopsy was at. It is possible that the biopsied tissue represents peripheral edge of a glioma. If this is a resection specimen, then MRI images need to be looked at carefully before making any judgement.