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3 楼 发表于2009-11-11 11:50:00举报|引用
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Although metastasis is the preferred possible diagnosis, the exact type and origin of malignancy are not very straight forward. The neoplastic cells seem to have a striking papillary architectural growth pattern and are associated with abundant hyalinized material - likely collagen or basement membrane material. I don't think this is a choroid plexus neoplasm, papillary glioneuronal tumor, or ependymoma. Metastatic adenocarcinoma with papillary growth pattern is my diagnosis. Immunohistochemical stains (TTF-1, AE1, S100, sm muscle actin, high molecular weight keratin 34betaE12) are required for further investigation of its primary origin.
Although metastasis is the preferred possible diagnosis, the exact type and origin of malignancy are not very straight forward. The neoplastic cells seem to have a striking papillary architectural growth pattern and are associated with abundant hyalinized material - likely collagen or basement membrane material. I don't think this is a choroid plexus neoplasm, papillary glioneuronal tumor, or ependymoma. Metastatic adenocarcinoma with papillary growth pattern is my diagnosis. Immunohistochemical stains (TTF-1, AE1, S100, sm muscle actin, high molecular weight keratin 34betaE12) are required for further investigation of its primary origin.
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